‘Cold’ Thyroid Nodule (Nucl) Fig. 16.16 A thyroid nodule: an area of decreased uptake on isotope scan. A ‘cold’ area in the lobe of the thyroid is shown. This appearance is due to a mass. Cysts, however, also display diminished uptake and an ultrasound scan is therefore needed in order to differentiate between a cyst and a solid lesion. See also: • Investigation of Malignant Thyroid Tumours.